IM2A - Institute of Memory and Alzheimer’s Disease 

IHU-A-ICM - Paris Institute of Translational Neurosciences

Pitié-Salpêtrière University Hospital, Pavillon F. Lhermitte

47-83 Boulevard de l'Hôpital, 75561 Paris Cedex 13, France

CURRENT RESEARCH TOPICS:

·   Alzheimer's Disease (AD) - Very early preclinical multimodal diagnosis for prevention and rehabilitation

·   Neurofeedback Treatment in  Alzheimer's Disease

CURRENT RESEARCH STUDIES / PROTOCOLS:

·   INSIGHT - INveStIGation of AlzHeimer’s PredicTors in Subjective Memory

                     [a longitudinal study, 400 subjects/visit, 2013-2018,

                     EEG, PET-amyloid, PET-FDG, MRI / fMRI / DTI / ASL, CSF, Actigraphy, neuropsychological tests, genomics,

                     transcriptomics, metabolomics, neurochemistry] 

·   ESTIMATE - NEw approacheS for The dIagnosis of AlzheiMer’s diseAse Through neuroElectrical changes in the brain

                     [a transversal study, 100 subjects, 2013-2016, EEG (electroencephalography), CSF, neuropsychological  tests]

·   SOCRATES - Structurizing and follow-up of a cohort in routine care concerning highly phenotyped patients with

                     Alzheimer's disease and related disorders

                     [a longitudinal multimodal biomarkers study, 100 subjects/year, 2014-2019,

                     PET-amyloid, PET-FDG, MRI / fMRI / DTI / ASL, CSF, neuropsychological tests, genomics, transcriptomics,

                     metabolomics, neurochemistry]

TEACHING ACTIVITIES (POSTGRADUATE STUDENTS)

·   Lecturer International Master Program “Bioengineering and Innovation in Neurosciences” - ESPCI ParisTech, ENSAM ParisTech, Paris Descartes universities (Paris, France)
·   Supervisor Master-Course Internships (M2 and M1) - Hôpital Pitié-Salpêtrière (Paris, France)
·   Adjunct Lecturer Master Program - Keio University (Tokyo, Japan)

BRIEF BIOGRAPHY:

PAST RESEARCH INTERESTS

·   Multi-Command SSVEP-BCI and Hybrid Brain-Computer Interfaces (BCI): SSVEP, P300, MI (motor imagery)

·   Affective-Visual Hybrid Brain-Computer Interface (BCI)

          Based on SSVEP and Emotions, with 8 and more commands

·   afSSVEP-BCI control of a robotic arm

          (e.g. serve a coffee cup to a handicapped subject, etc)

·   Hyperscanning: Simultaneous brain activity in a group of human subjects

          during  shared social experiences and communication

·   Rehabilitation: Brain recovery through targeted changes

·   Sensory enhancement using emotions

          (Affective-Face Steady-State Visual Evoked Responses - afSSVEP))

·   Emotions: Adaptive recognition using biosignals (actual and imagined stimuli)

·   Music therapy in advanced dementia

·   Multisensory brain interactions (visual, auditory, somatosensory, etc)

·   Fast visual motion processing in the brain (apparent and smooth)

·   Fast alternative BCI designs based on visual-motion imagery with priming

·   Non-lingual infant-adult communications based on brain activity;

    Multi-sensory enhancements of infant cognitive development

·   Neurofeedback  paradigms for drug-free treatment

·   Contactless brain sensors for BCI and neurofeedback therapy

WORK OBJECTIVES

·   To achieve innovative research results in service of society through new experimental designs and advanced signal processing leading

    to progress in understanding and control of important functions of the human body (e.g. brain)

·   To develop biomedical knowledge, novel technology and challenging practical applications for the substantial improvement of quality of

    life of healthy, elderly, very young, and disabled members of society.

·   To transfer knowledge and skills to the younger generation by teaching and hands-on approach

PROFESSIONAL SOCIETY MEMBERSHIPS

·   IEEE Society

·   ISTAART Society (Alzheimer's Association - International Society to Advance Research and Treatment)

·   Japan Neuroscience Society (JNS & IBRO)

·   Society for Neuroscience

JOURNAL REVIEWER ACTIVITIES

·   Biological Psychology

·   Biomedical Signal Processing and Control
·   Brain Research

·   Clinical Neurophysiology

·   Computational Intelligence and Neuroscience

·   Computers in Biology and Medicine

·   IEEE Transactions on Neural Systems & Rehabilitation Engineering
·   IEEE Transactions on Systems, Man, and Cybernetics
·   Journal of Neural Engineering
·   Journal of Alzheimer's Disease
·   Medical Engineering & Physics
·   NeuroImage
·   NeuroReport
·   NeuroScience Letters
·   PLoS ONE

LANGUAGES

·   1992 - Young Scientist Prize for Clinical Sciences - Federation of Medical Science Societies, Bulgaria

·   Sept.1992 - Austrian Ministry of Education research fellowship: Technical University of Graz, Graz, Austria
·   April 1993 - Japanese Ministry of Education research fellowship: Hokkaido University, Sapporo, Japan

·   Dec. 1997 - Japanese STA (Science and Technology Agency) fellowship, Ministry of International Trade and Industry: AIST
                     National Institute of Bioscience and Human-Technology (NIBH), Tsukuba, Japan
·   2011 - Excellent Session Organizer Award,  RIKEN-BSI Retreat 2011, Karuizawa city,  Japan    

VOLUNTEER ACTIVITIES

·   (2000-) Inter-cultural coordination, translation, and advisory activities to help build a working long-term communication
	bridge between Japanese sculptor Mr. Masaji Asaga, and Bulgarian sculptors and artists (Mr. Ivan Russev, Prof. Stefan Lyutakov,
	Ms. Snezhana Simeonova, Mr. Ziyatin Nuriev, Mr. Tsviatko Siromashki, Mr. Milan Andreev, Mr. Kiril Meshkin and others).