Project Leader for Electrophysiology & Multimodality



SSVEP data (Bakardjian)

Hova Bakardjian @ LABSP
Hova Bakardjian: 256-channel EEG Experiment (EGI)
Hova Bakardjian with EEG subject (256-channel EGI) at IM2A
Model of Emotion-Vision Interactions (Bakardjian 2011)
Hova Bakardjian
Visiting Researcher - RIKEN,Brain Science Inst., LABSP (Wako,Saitama,Japan)

Visiting Researcher - ESPCI ParisTech, Laboratoire SIGMA (Paris, France)
Visiting Associate Professor - Keio University (Tokyo, Japan)

(INSERM Research Unit U1127)

IM2A - Institute of Memory and Alzheimer’s Disease 

IHU-A-ICM - Paris Institute of Translational Neurosciences

Pitié-Salpêtrière University Hospital, Pavillon F. Lhermitte

47-83 Boulevard de l'Hôpital, 75561 Paris Cedex 13, France

Work web page:
Private web page:
Tel: (+33) 1 42 16 19 25


·   Alzheimer's Disease (AD) - Very early preclinical multimodal diagnosis for prevention and rehabilitation

·   Neurofeedback Treatment in  Alzheimer's Disease


·   INSIGHT - INveStIGation of AlzHeimer’s PredicTors in Subjective Memory

                     [a longitudinal study, 400 subjects/visit, 2013-2018,

                     EEG, PET-amyloid, PET-FDG, MRI / fMRI / DTI / ASL, CSF, Actigraphy, neuropsychological tests, genomics,

                     transcriptomics, metabolomics, neurochemistry] 

·   ESTIMATE - NEw approacheS for The dIagnosis of AlzheiMer’s diseAse Through neuroElectrical changes in the brain

                     [a transversal study, 100 subjects, 2013-2016, EEG (electroencephalography), CSF, neuropsychological  tests]

·   SOCRATES - Structurizing and follow-up of a cohort in routine care concerning highly phenotyped patients with

                     Alzheimer's disease and related disorders

                     [a longitudinal multimodal biomarkers study, 100 subjects/year, 2014-2019,

                     PET-amyloid, PET-FDG, MRI / fMRI / DTI / ASL, CSF, neuropsychological tests, genomics, transcriptomics,

                     metabolomics, neurochemistry]


·   Lecturer International Master Program “Bioengineering and Innovation in Neurosciences” - ESPCI ParisTech, ENSAM ParisTech, Paris Descartes universities (Paris, France)
·   Supervisor Master-Course Internships (M2 and M1) - Hôpital Pitié-Salpêtrière (Paris, France)
·   Adjunct Lecturer Master Program - Keio University (Tokyo, Japan)


Hovagim Bakardjian is with the IHU-A-ICM - Paris Institute of Translational Neurosciences and the IM2A - Institute of Memory and Alzheimer’s Disease at the Pitié-Salpêtrière University Hospital in Paris, France. As a project leader for the electrophysiology platform and a coordinator for the multimodality research data, he is a member of a multidisciplinary research team working towards very early diagnosis of Alzheimer’s Disease (AD) in its preclinical (asymptomatic-at-risk and prodromal) stages (for definitions see 1, 2, 3). This clinical research involves the full or partial management of three large-scale projects, as well as the creation and advanced signal processing analysis of a database of longitudinal measurements of data from 500+ subjects per year including patients in various stages of AD, as well as healthy subjects. The new approach to individual AD diagnosis in the INSIGHT project in particular is based on EEG, MRI / fMRI / DTI, PET-FDG, PET-Amyloid, CSF, vascular, genetic, transcriptomic, metabolomic, neurochemical and other multimodal biomarkers, with the ultimate goal of reliable early prediction of conversion to AD in the clinical practice.
Hovagim strives to combine the computational, experimental and clinical approaches in neuroscience to achieve maximal contribution for the elderly, disabled, and healthy members of society using novel neuro-technologies. He has more than 90 research publications and is a member of the SfN (Society for Neuroscience), the ISTAART Society (Alzheimer's Association – Intern. Soc. to Advance Research and Treatment), IEEE (Inst. of Electrical and Electronics Engin.), and the JNS (Japan Neuroscience Soc.).


·   Multi-Command SSVEP-BCI and Hybrid Brain-Computer Interfaces (BCI): SSVEP, P300, MI (motor imagery)

·   Affective-Visual Hybrid Brain-Computer Interface (BCI)

          Based on SSVEP and Emotions, with 8 and more commands

·   afSSVEP-BCI control of a robotic arm

          (e.g. serve a coffee cup to a handicapped subject, etc)

·   Hyperscanning: Simultaneous brain activity in a group of human subjects

          during  shared social experiences and communication

·   Rehabilitation: Brain recovery through targeted changes

·   Sensory enhancement using emotions

          (Affective-Face Steady-State Visual Evoked Responses - afSSVEP))

·   Emotions: Adaptive recognition using biosignals (actual and imagined stimuli)

·   Music therapy in advanced dementia

·   Multisensory brain interactions (visual, auditory, somatosensory, etc)

·   Fast visual motion processing in the brain (apparent and smooth)

·   Fast alternative BCI designs based on visual-motion imagery with priming

·   Non-lingual infant-adult communications based on brain activity;

    Multi-sensory enhancements of infant cognitive development

·   Neurofeedback  paradigms for drug-free treatment

·   Contactless brain sensors for BCI and neurofeedback therapy


·   To achieve innovative research results in service of society through new experimental designs and advanced signal processing leading

    to progress in understanding and control of important functions of the human body (e.g. brain)

·   To develop biomedical knowledge, novel technology and challenging practical applications for the substantial improvement of quality of

    life of healthy, elderly, very young, and disabled members of society.

·   To transfer knowledge and skills to the younger generation by teaching and hands-on approach


·   IEEE Society

·   ISTAART Society (Alzheimer's Association - International Society to Advance Research and Treatment)

·   Japan Neuroscience Society (JNS & IBRO)

·   Society for Neuroscience


·   Biological Psychology
·   Biomedical Signal Processing and Control
·   Brain Research

·   Clinical Neurophysiology

·   Computational Intelligence and Neuroscience

·   Computers in Biology and Medicine

·   IEEE Transactions on Neural Systems & Rehabilitation Engineering
·   IEEE Transactions on Systems, Man, and Cybernetics
·   Journal of Neural Engineering
·   Journal of Alzheimer's Disease
·   Medical Engineering & Physics
·   NeuroImage
·   NeuroReport
·   NeuroScience Letters
·   PLoS ONE


English, French, German, Japanese, Bulgarian, Russian, Armenian

·   1992 - Young Scientist Prize for Clinical Sciences - Federation of Medical Science Societies, Bulgaria
·   Sept.1992 - Austrian Ministry of Education research fellowship: Technical University of Graz, Graz, Austria
·   April 1993 - Japanese Ministry of Education research fellowship: Hokkaido University, Sapporo, Japan
·   Dec. 1997 - Japanese STA (Science and Technology Agency) fellowship, Ministry of International Trade and Industry: AIST
National Institute of Bioscience and Human-Technology (NIBH), Tsukuba, Japan
·   2011 - Excellent Session Organizer Award, RIKEN-BSI Retreat 2011, Karuizawa city, Japan


·   (2000-) Inter-cultural coordination, translation, and advisory activities to help build a working long-term communication
bridge between Japanese sculptor Mr. Masaji Asaga, and Bulgarian sculptors and artists (Mr. Ivan Russev, Prof. Stefan Lyutakov,
Ms. Snezhana Simeonova, Mr. Ziyatin Nuriev, Mr. Tsviatko Siromashki, Mr. Milan Andreev, Mr. Kiril Meshkin and others).

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